Now Available: Final Rule for FDAAA 801 and NIH Policy on Clinical Trial Reporting School Inner-City Asthma Intervention Study (SICAS-2) (SICAS-2) This study is currently recruiting participants. (see Contacts and Locations) Other: integrated pest management Other: No intervention (control) Allocation: RandomizedEndpoint Classification: Efficacy StudyIntervention Model: Factorial AssignmentMasking: Double Blind (Subject, Investigator)Primary Purpose: Treatment School Inner-City Asthma Intervention Study asthma symptoms [ Time Frame: two weeks ] [ Designated as safety issue: No ]Maximum number of Days with wheezing, tightness in the chest, or cough and/or Nights with disturbed sleep as a result of asthma and/or Days on which the child had to slow down or discontinue play activities because of asthma health care utilization [ Time Frame: 3 months ] [ Designated as safety issue: No ] lung function [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Fractional exhaled nitric oxide (FeNO) [ Time Frame: 12 months ] [ Designated as safety issue: No ] rescue medications [ Time Frame: 12 months ] [ Designated as safety issue: No ] exacerbations [ Time Frame: 12 months ] [ Designated as safety issue: No ] asthma control [ Time Frame: 12 months ] [ Designated as safety issue: No ] school absences [ Time Frame: 12 months ] [ Designated as safety issue: No ] change in care taker plans [ Time Frame: 12 months ] [ Designated as safety issue: No ] composite asthma severity index [ Time Frame: 12 months ] [ Designated as safety issue: No ] missed caretaker sleep [ Time Frame: Days of lost sleep/ 2 weeks ] [ Designated as safety issue: No ] Estimated Study Completion Date: Estimated Primary Completion Date: September 2020 (Final data collection date for primary outcome measure) Active Comparator: Environmental Intervention

Placebo Comparator: Sham and Control Placebo Comparator: Active Air Purifier and Control Sham Comparator: Sham and Inegrated Pest Ages Eligible for Study: 4 Years to 15 Years   (Child) Genders Eligible for Study: grades K-8 with asthma attending sampling/intervention schools Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies. Please refer to this study by its ClinicalTrials.gov identifier: NCT02291302 Contact: Wanda Phipatanakul, MD, MS Boston, Massachusetts, United States, 02115 Contact: Wanda Phipatanakul       asthma@childrens.harvard.edu Principal Investigator: Wanda Phipatanakul, MD,MS Wanda Phipatanakul, MD, MS Wanda Phipatanakul, Associate Professor of Pediatrics, Children's Hospital Boston

Other Study ID Numbers: United States: Institutional Review Board Additional relevant MeSH terms: Freedom of Information Act U.S. National Library of Medicine U.S. National Institutes of Health U.S. Department of Health and Human Services Sodium hypochlorite is a chemical commonly found in bleach, water purifiers, and cleaning products.Swallowing sodium hypochlorite can lead to poisoning. Breathing sodium hypochlorite fumes may also cause poisoning, especially if the product is mixed with ammonia.paintball gun cleaning mopThis article is for information only. hunter air purifier discontinuedDo NOT use it to treat or manage an actual poison exposure. air duct cleaning chapel hill ncIf you or someone you are with has an exposure, call your local emergency number (such as 911), or your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.Sodium hypochloriteSodium hypochlorite is found in:Chemical used to add chlorine to swimming poolsDisinfectantsSome bleaching solutionsWater purifiers Note: This list may not be all inclusive.

Watered-down (diluted) sodium hypochlorite generally causes only mild stomach irritation. Swallowing larger amounts can cause more serious symptoms. Industrial-strength bleach contains much higher concentrations of sodium hypochlorite, which may cause severe injury.NEVER mix ammonia with sodium hypochlorite (bleach or bleach-containing products). This common household error produces a toxic gas that can cause choking and serious breathing problems. Symptoms of sodium hypochlorite poisoning may include:Burning, red eyesChest painComaCoughing (from the fumes)DeliriumGagging sensationLow blood pressurePain in the mouth or throatPossible burns on the esophagusSkin irritation of the exposed area, burns, or blisteringShockSlow heartbeatStomach or abdominal painVomiting Seek immediate medical help. DO NOT make a person throw up unless told to do so by Poison Control or a health care professional.If the chemical is on the skin or in the eyes, flush with lots of water for at least 15 minutes.If the chemical was swallowed, immediately give the person water or milk, unless instructed otherwise by a health care provider.

DO NOT give water or milk if the person is having symptoms (such as vomiting, convulsions, or a decreased level of alertness) that make it hard to swallow.If the person breathed in the poison, immediately move him or her to fresh air. Determine the following information:The person's age, weight, and conditionThe name of the product (ingredients and strengths, if known)The time it was swallowedThe amount swallowed However, DO NOT delay calling for help if this information is not immediately available.Your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This hotline number will let you talk to experts in poisoning. They will give you further instructions.This is a free and confidential service. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.The person will be admitted to a hospital.

The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated as appropriate. The person may receive:Airway support, including oxygen, breathing tube through the mouth (intubation), and breathing machine (ventilator)Blood and urine testsCamera down the throat (endoscopy) to see burns in the esophagus and stomachChest x-rayEKG (electrocardiogram, or heart tracing)Fluids through a vein (IV)Medicines to treat symptoms Note: Activated charcoal does not effectively treat (adsorb) sodium hypochlorite.For skin exposure, treatment may include:Irrigation (washing of the skin), possibly every few hours for several daysSurgical removal of burned skin (skin debridement)Transfer to a hospital that specializes in burn care The person may need to be admitted to a hospital to continue treatment. Surgery may be needed if the esophagus, stomach, or intestine have holes (perforations) from the acid.Swallowing, smelling, or touching household bleach will likely not cause any significant problems.

However, more severe problems can occur with industrial-strength bleach, or from mixing bleach with ammonia.How well a person does depends on how rapidly the sodium hypochlorite was diluted and neutralized. There is a good chance of recovery if proper treatment is given soon after the poison was swallowed. Without prompt treatment, extensive damage to the mouth, throat, eyes, lungs, esophagus, nose, and stomach are possible, depending on how exposure occurred.Carrel-Dakin solutionAgabiti N, Ancona C, Forastiere F, et al. Short term respiratory effects of acute exposure to chlorine due to a swimming pool accident. Occup Environ Med. 2001 Jun;58(6):399-404. Lambert H, Manel J, Gabrion I. Poisoning by household products. Wax PM, Young A. Caustics. In: Marx JA, Hockberger RS, Walls RM, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 8th ed. Philadelphia, PA: Elsevier Saunders; Updated by: Jacob L. Heller, MD, MHA, Emergency Medicine, Virginia Mason Medical Center, Seattle, WA.