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this item all sold out ,currenly no sotck . 5years local warranty . Philips Air Purifier Humidifier AC4081Question : StocksAnswer : [Re] StocksHi , thank you for enquiry . Sorry , currently no stock . 23 Sep 2016 - 06 Oct 2016 What's New Mr Clean What's New L'oreal Paris What's Exclusive Mamil Gold 23 Sep 2016 - 29 Sep 2016 23 Sep 2016 - 25 Sep 2016 22 Sep 2016 - 05 Oct 2016 All Time Favourite Wine 22 Sep 2016 - 28 Sep 2016 16 Sep 2016 - 12 Oct 2016 16 Sep 2016 - 30 Sep 2016 16 Sep 2016 - 29 Sep 2016 What's Exclusive Old Town 09 Sep 2016 - 06 Oct 2016 09 Sep 2016 - 30 Sep 2016 02 Sep 2016 - 30 Sep 2016 What's Exclusive Uji Cha 02 Sep 2016 - 29 Sep 2016 What’s Exclusive TOP Nanox and Mama Magica 26 Aug 2016 - 30 Sep 2016 The Conversion of Vitamin K Epoxide to Vitamin K Quinone and Vitamin K Quinone to Vitamin K Hydroquinone Uses the Same Active Site Cysteines†DOI: Abstract Vitamin K epoxide (or oxido) reductase (VKOR) is the target of warfarin and provides vitamin K hydroquinone for the carboxylation of select glutamic acid residues of the vitamin K-dependent proteins which are important for coagulation

, signaling, and bone metabolism. It has been known for at least 20 years that cysteines are required for VKOR function. To investigate their importance, we mutated each of the seven cysteines in VKOR. In addition, we made VKOR with both C43 and C51 mutated to alanine (C43A/C51A), as well as a VKOR with residues C43−C51 deleted. Each mutated enzyme was purified and characterized. We report here that C132 and C135 of the CXXC motif are essential for both the conversion of vitamin K epoxide to vitamin K and the conversion of vitamin K to vitamin K hydroquinone. Surprisingly, conserved cysteines, 43 and 51, appear not to be important for either reaction. For the in vitro reaction driven by dithiothreitol, the 43−51 deletion mutation retained 85% and C43A/C51A 112% of the wild-type activity. The facile purification of the nine different mutations reported here illustrates the ease and reproducibility of VKOR purification by the method reported in our recent publication [Chu, P.-H., Huang, T.-Y., Williams, J., and Stafford, D. W. (2006) Proc. Natl. Acad. Sci. U S A. 103, 19308−19313].

Membrane Composition Influences the Activity of in Vitro Refolded Human Vitamin K Epoxide Reductase , , , and 2015 AbstractPDF w/ LinksHuman teratogens and genetic phenocopies. Understanding pathogenesis through human genes mutation , , , , 2016 Structural and functional insights into enzymes of the vitamin K cycle , 2016 Altered membrane protein assembly machinery allows proper membrane assembly of eukaryotic protein vitamin K epoxide reductase , , , , , , , 2015 Effects of NAD(P)H quinone oxidoreductase 1 polymorphisms on stable warfarin doses in Korean patients with mechanical cardiac valves , , , , 2015 Tris(3-hydroxypropyl)phosphine (THPP): A mild, air-stable reagent for the rapid, reductive cleavage of small-molecule disulfides , , , 2015 VKORC1 and VKORC1L1: Why do Vertebrates Have Two Vitamin K 2,3-Epoxide Reductases? , , 2015 7Structural Modeling Insights into Human VKORC1 Phenotypes , , 2015 7Tris(3-hydroxypropyl)phosphine is superior to dithiothreitol for in vitro assessment of vitamin K 2,3-epoxide reductase activity , , , , 2015 Disulfide bond formation in prokaryotes: History, diversity and design , , 2014 Comparative genetics of warfarin resistance , , , , 2014 The Molecular Basis of Blood Coagulation , 2014Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces

, , , , , , 2013 Structural Basis of Disulfide Bond Formation in the Bacterial Periplasm and Mammalian ER , , 2013The oxidative protein folding machinery in plant cells , 2013 Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay , , , , , , 2013 Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like1 2013 A new cell culture-based assay quantifies VKORC1 function and reveals warfarin resistance phenotypes not shown by the DTT-driven VKOR assay , , , , , , , , 2013 VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity , , , , , , 2012 Mycobacterium tuberculosis Vitamin K Epoxide Reductase Homologue Supports Vitamin K–Dependent Carboxylation in Mammalian Cells , , 2011 Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants , , , , 2011 Multiple ways to make disulfides , 2011 More on: endoplasmic reticulum loop VKORC1 substitutions cause warfarin resistance but do not diminish gamma-carboxylation of the vitamin K-dependent coagulation factors , , , , 2011 9Functional study of the vitamin K cycle in mammalian cells

, , , 2011 Warfarin in haemodialysis patients with atrial fibrillation: what benefit? , , , 2010 Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insight into improved patient diagnosis and treatment , , , , , , , , 2010 Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners , , , 2010 A comparative proteomic analysis of HepG2 cells incubated by S(−) and R(+) enantiomers of anti-coagulating drug warfarin , , , , 2010 Structure of a bacterial homologue of vitamin K epoxide reductase , , , , , 2010 Use of Warfarin in People with Low Glomerular Filtration Rate or on Dialysis , 2009 Vitamin K-Dependent Carboxylase and Vitamin K Epoxide Reductase 2009Association of Sequence Variations in Vitamin K Epoxide Reductase and γ-Glutamyl Carboxylase Genes with Biochemical Measures of Vitamin K Status , , , , , 2009 Familial deficiency of vitamin K-dependent clotting factors , 2008 Structure and Function of Vitamin K Epoxide Reductase , 2008The Vitamin K Cycle , , , 2008Vascular calcification in chronic kidney disease: the role of vitamin K