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(Yamato TAQBIN is currently available only on selected States in Malaysia) ShaShinKi - the Largest Online Camera Shop! Signup ShaShinKi's Newsletter and get FREE RM10 Shopping Point! Over 19,500 Photographic Equipment Online! Malaysia's First and Largest Online Camera Shop! or t: 07-5589122 or m / WhatsApp: +60167736586 Calumet Adapter Ring for Profoto For use with Calumet Sofboxes on Profoto Heads. Please note that additional Speed Ring is required.Your cart is currently empty Photochemical & Photobiological Sciences Comparative kinetics of damage to the plasma and mitochondrial membranes by intra-cellularly synthesized and externally-provided photosensitizers using multi-color FACS Photodynamic therapy (PDT) of cancer involves inflicting lethal damage to the cells of malignant tumors, primarily by singlet oxygen that is generated following light-absorption in a photosensitizer molecule. Dysfunction of cells is manifested in many ways, including peroxidation of cellular components, membrane rupture, depolarization of electric potentials, termination of mitochondrial activity, onset of apoptosis and necrosis and eventually cell lysis.

These events do not necessarily occur in linear fashion and different types of damage to cell components occur, most probably, in parallel. In this report we measured the relative rates of damage to two cellular membranes: the plasma membrane and the mitochondrial membrane. We employed photosensitizers of diverse hydrophobicities and used different incubation procedures, which lead to their different intra-cellular localizations. We monitored the damage that was inflicted on these membranes, by employing optical probes of membrane integrity, in a multi-color FACS experiment. The potentiometric indicator JC-1 monitored the electric cross-membrane potential of the mitochondria and the fluorometric indicator Draq7 monitored the rupture of the plasma membrane. We show that the electric depolarization of the mitochondrial membrane and the damage to the enveloping plasma membrane proceed with different kinetics that reflect the molecular character and intracellular location of the sensitizer: PpIX that is synthesized in the cells from ALA causes rapid mitochondrial damage and very slow damage to the plasma membrane, while externally added PpIX has an opposite effect.

The hydrophilic sensitizer HypS4 can be taken up by the cells by different incubation conditions, and these affect its intracellular location, and as a consequence either the plasma membrane or the mitochondria is damaged first. A similar correlation was found for additional extracellularly-provided photosensitizers HP and PpIX. Submit to this JournalLooking for a friendly, community pub serving real ale in Tottenham, north London? A place to meet and make friends before or after Spurs matches at nearby White Hart Lane?  A pub in N17 that is dog friendly, to make your own home from home – a venue to come to listen to live music free, for a coffee, watch sports live on tv, to use free WiFi, to start or join a club in, or to hire out for your own event? Tucked away in the historic and atmospheric Bruce Castle Park area, The Antwerp Arms is Tottenham’s longest established working pub. Serving local people since 1822, our Georgian building with beer garden, faced demolition in 2013 – before over 300 of us came together to own and run it.